Développement de médicaments

Publications scientifiques

Shigamabs

• 2006-10 Renal Involvement in Children with STEC Colitis (PDF: 2,21 Mo)
• 2006-10 Epidemiological Evaluation of Shiga Toxin Producing Escherichia coli (STEC) Infections in the European Community (PDF: 3,89 Mo)

TLN-4601

• 2008-10 Biological and Biochemical Activity of TLN-4601 in Pancreatic Cancer (PDF: 292 Ko)
• 2008-07 Induction of Apoptosis in Immortalized T-Lymphocytes by TLN-4601 is Independent of Peripheral Benzodiazepine Receptor (PBR/TSPO) Binding (PDF: 1,21 Mo)
• 2008-04 Identification, characterization and potent antitumor activity of ECO-4601, a novel peripheral benzodiazepine receptor ligand.
• 2008-04 TLN-4601:A Potential New Therapeutic for the Treatment of Mutated K-Ras Mediated Cancers (PDF: 853 Ko)
• 2008-04 A structurally novel farnesylated dibenzodiazepinone, TLN-4601, inhibits wild-type, amplified and mutated EGFR glioma cell migration (PDF: 283 Ko)
• 2007-11 Targeted Delivery of ECO-4601 to Brain Tumors in an Orthotopic Model (PDF: 362 Ko)
• 2007-11 Safety and Efficacy of ECO-4601, a Novel Ras/MAPK Pathway Inhibitor and PBR Targeting Agent, in a Phase I Clinical Trial (PDF: 326 Ko)
• 2007-10 Phase I Pharmacokinetic Study of ECO-4601, a Novel Anticancer Bifunctional Targeting Agent (PDF: 242 Ko)
• 2007-04 ECO-4601, a novel anticancer drug and PBR ligand induces apoptosis through caspase-mediated events (PDF: 683 Ko)
• 2006-12 ECO-4601, A NOVEL ANTITUMOR COMPOUND TARGETING THE RAS-MAPK PATHWAY INDUCES APOPTOSIS (PDF: 2,09 Mo)
• 2006-11 The Anticancer Agent, ECO-4601, is a Potent Inhibitor of the Ras-Mitogen-Activated Protein Kinase Pathway (PDF: 655 Ko)
• 2006-11 Safety Profile in Primates of the Anticancer Agent ECO-4601, a Novel PBR Ligand and Ras Signalling Inhibitor (PDF: 240 Ko)
• 2006-08 ECO-4601, a Novel Peripheral Benzodiazepine Receptor Ligand, is also a Potent Inhibitor of the Ras-Mitogen-Activated Protein Kinase Pathway (PDF: 847 Ko)
• 2005-11 Antitumor Efficacy of ECO-4601 in Human Breast and Prostate Tumor Xenografts Correlates with Low and Sustained Drug Plasma Levels (PDF: 250 Ko)
• 2004-09 A NEW ANTITUMOR COMPOUND, ECO-4601: PRECLINICAL EVALUATION AND IN VIVO EFFICACY IN GLIOMA (PDF: 311 Ko)
• 2004-03 IDENTIFICATION AND CHARACTERIZATION OF A NEW CYTOTOXIC AGENT FROM ACTINOMYCETES (ECO-04601) (PDF: 243 Ko)

TLN-232

• 2008-09 PHASE II STUDY OF TLN-232, A NOVEL M2PK TARGETING AGENT, ADMINISTERED BY CIV TO PATIENTS WITH ADVANCED RENAL CELL CARCINOMA (RCC) (PDF: 347 Ko)